March 2010

LVEM5 Desktop TEM used to image Dendrimers

LVEM5 used for Dendrimer Imaging

Applications in drug delivery

University of Michigan (Ann Arbor, MI)


We have found that the LVEM can provide high contrast images of a wide variety of samples, including dendrimers

Denrimers

Relative newcomers to the collection of materials used for drug delivery are dendrimers, a type of highly branched macromolecule. One of the major advantages of dendrimers is their relatively small size, according to James R. Baker Jr., director of the Center for Biological Nanotechnology at the University of Michigan. “We can get a platform that we can target that’s less than 5 nm in diameter. It provides a very nice scaffold and one that certainly can get through vascular pores and into tissue more efficiently than larger carriers,” he says.


Another advantage of dendrimers is that their synthesis results in a single molecular weight rather than a distribution of sizes. “Although they’re rather complicated, they can be synthesized so that you have a single molecular weight, a single species in the bottle,” notes Duncan, who also works with dendrimers.


In addition, dendrimers have a high drug-carrying capacity because of their multivalency, according to Jean M. J. Frechet, a chemistry professor at the University of California, Berkeley. “You have many functional groups and can deliver a high payload,” he says. “If you spend the effort for targeting, you are targeting a high payload as opposed to a single molecule.”


(Courtesy of: Celia Henry Arnaud, Chemical and Engineering News, August 26, 2002, Volume 80, Number 34, CENEAR 80 34 pp. 39-47, ISSN 0009-2347)



Publication


High Resolution Electron Microscopy of Ordered Polymers and Organic Molecular Crystals: Recent Developments and Future Possibilities


DAVID C. MARTIN, JIHUA CHEN, JUNYAN YANG, LAWRENCE F. DRUMMY, CHRISTIAN KU¨ BEL

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